Additional Information on Regenerative Medicine

Published Animal Research on Regenerative Medicine

Soft Tissue

  • Kamoto N, et al. Treating Achilles tendon rupture in rats with bone-marrow transplantation therapy. (2010) Journal Bone Joint Surgery. 92(17): 2776-84
  • Torricetie P, et al. Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses. (2011) International Orthopaedics. 35(100): 1569-76.
  • Xie X, et al. The effect of platelet-rich plasma on patterns of gene expression in a dog model of anterior cruciate ligament reconstruction. (2013) Journal 0f Surgical Research. 190(1):80-8.

Osteoarthritis and Cartilage Defects

  • Franklin SP, et al. Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs. (2013) Canadian Vet Journal. 54(9): 881-4.
  • Guercio A, et al. Production of canine mesenchymal stem cells from adipose tissue and application in dogs with chronic osteoarthritis of the humeroredal joints. (2012) Cell Bio International. 36(2):189-94
  • Johnson K, et al. A stem cell based approach to cartilage repair. (2012) Science. 336(6082):717-21.
  • Mokbel A., et al. Homing and efficacy of intra-articular injection of autologous mesenchymal stem cells in experimental chondral defects in dogs. (2011) Clinical and Experimental Rheumatology. 29(2): 275-84.

Neurological Disease

  • Bong Wook Park, et al. Peripheral nerve regeneration using autologous porcine skin-derived mesenchymal stem cells. (2012) Journal of Tissue Engineering and Regenerative Medicine. 6(2):113-24
  • Dong-In Jung, et al. A comparison of autologous and allogenic bone marrow derived mesenchymal stem cell transplantation in canine spinal cord injury. (2009). Journal of the Neurological Sciences. 285(1):67-77.
  • Hak Hyun Ryu, et al. Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury. (2009) Journal of Veterinary Science. 10(4):273-84.
  • Ren Z, et al. Role of stem cells in the regeneration and repair of peripheral nerves. (2012) Reviews in the Neurosciences. 23(2):135-43.

Bone Growth/ Regeneration

  • Cho AR, et al. The incorporation of platelet-rich plasma into calcium phosphate cement enhances bone regeneration in osteoporosis. (2014) Pain Physician. 17(6): E737-45

Additional Literature on PRP benefits

Tendon Injuries

  • Ahmad Z, et al. Exploring the application of stem cells in tendon repair and regeneration. (2012) Arthroscopy. 28(7):1018-29.
  • Chen L, et al. Synergy of tendon stem cells and platelet-rich plasma in tendon healing. (2012) Journal of Orthopedic Research. 30(6): 991-7.
  • De Almeida AM, et al. Patellar tendon healing with platelet-rich plasma: a prospective randomized controlled trial. (2012) American Journal Sports Medicine. 40(6):1282-8.
  • Finnoff et al. Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection. (2011) PM&R. 3(10):900-11.
  • Mont RR, et al. Platelet rich plasma treatment for chronic Achilles tendinosis. (2012) Foot Ankle International. 33(5):379-85.
  • Nixon AJ. Cell and gene-based approaches to tendon regeneration. (2012) Journal of Shoulder Elbow Surgery. 21(2):278-94.

Osteoarthritis

  • Ahadi T., et al. Platelet-rich plasma versus hyaluronic acid. (2012) Arthroscopy. 28(11):1585-6
  • Anitua E., et al. A biological therapy to osteoarthritis treatment using platelet-rich plasma. (2013) Expert Opinion Biologic Therapy. 13(8):1161-72.
  • Pourcho AM, et al. Intra articular platelet-rich plasma injections in the treatment of knee osteoarthritis: review and recommendations. (2014) American Journal Physiology, Medicine and Rehabilitation. 93(11 Suppl 3):S108-21.
  • Zhu Y, et al. Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review. (2013) J. Osteoarthritic Cartilage. 21(11):1627-37

Rotator Cuff Injuries

  • Isaac C, et al. Biologic approaches to enhance rotator cuff healing after injury. (2012) Journal of Shoulder Elbow Surgery. 21(2):181-90.

Bone Growth/ Reconstruction

  • Loquercio G, et al. Autologous platelet gel improves bone reconstruction of large defects in patients with bone giant cell tumors. (2015) In Vivo. 29(5): 533-540.
  • Eskan MA, et al. Platelet-rich plasma-assisted guided bone regeneration for ridge augmentation: a randomized, controlled clinical trial. (2014) Journal of Periodontology. 85(5): 661-8.